Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell–associated damage in IFNα-driven lupus nephritis

Systemic lupus erythematosus (SLE) is often associated with exaggerated B cell activation promoting plasma cell generation, immune-complex deposition in the kidney, renal infiltration of myeloid cells, and glomerular nephritis. Type-I IFNs amplify these autoimmune processes and promote severe diseas...

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Bibliografske podrobnosti
izdano v:JCI Insight
Main Authors: Katewa, Arna, Wang, Yugang, Hackney, Jason A., Huang, Tao, Suto, Eric, Ramamoorthi, Nandhini, Austin, Cary D., Bremer, Meire, Chen, Jacob Zhi, Crawford, James J., Currie, Kevin S., Blomgren, Peter, DeVoss, Jason, DiPaolo, Julie A., Hau, Jonathan, Johnson, Adam, Lesch, Justin, DeForge, Laura E., Lin, Zhonghua, Liimatta, Marya, Lubach, Joseph W., McVay, Sami, Modrusan, Zora, Nguyen, Allen, Poon, Chungkee, Wang, Jianyong, Liu, Lichuan, Lee, Wyne P., Wong, Harvey, Young, Wendy B., Townsend, Michael J., Reif, Karin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2017
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374071/
https://ncbi.nlm.nih.gov/pubmed/28405610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90111
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