Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell–associated damage in IFNα-driven lupus nephritis

Systemic lupus erythematosus (SLE) is often associated with exaggerated B cell activation promoting plasma cell generation, immune-complex deposition in the kidney, renal infiltration of myeloid cells, and glomerular nephritis. Type-I IFNs amplify these autoimmune processes and promote severe diseas...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Katewa, Arna, Wang, Yugang, Hackney, Jason A., Huang, Tao, Suto, Eric, Ramamoorthi, Nandhini, Austin, Cary D., Bremer, Meire, Chen, Jacob Zhi, Crawford, James J., Currie, Kevin S., Blomgren, Peter, DeVoss, Jason, DiPaolo, Julie A., Hau, Jonathan, Johnson, Adam, Lesch, Justin, DeForge, Laura E., Lin, Zhonghua, Liimatta, Marya, Lubach, Joseph W., McVay, Sami, Modrusan, Zora, Nguyen, Allen, Poon, Chungkee, Wang, Jianyong, Liu, Lichuan, Lee, Wyne P., Wong, Harvey, Young, Wendy B., Townsend, Michael J., Reif, Karin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374071/
https://ncbi.nlm.nih.gov/pubmed/28405610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90111
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