APOL1 Renal-Risk Variants Induce Mitochondrial Dysfunction

APOL1 G1 and G2 variants facilitate kidney disease in blacks. To elucidate the pathways whereby these variants contribute to disease pathogenesis, we established HEK293 cell lines stably expressing doxycycline-inducible (Tet-on) reference APOL1 G0 or the G1 and G2 renal-risk variants, and used Illum...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Ma, Lijun, Chou, Jeff W., Snipes, James A., Bharadwaj, Manish S., Craddock, Ann L., Cheng, Dongmei, Weckerle, Allison, Petrovic, Snezana, Hicks, Pamela J., Hemal, Ashok K., Hawkins, Gregory A., Miller, Lance D., Molina, Anthony J.A., Langefeld, Carl D., Murea, Mariana, Parks, John S., Freedman, Barry I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2017
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373457/
https://ncbi.nlm.nih.gov/pubmed/27821631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016050567
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