Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells

Two APOL1 gene variants, which likely evolved to protect individuals from African sleeping sickness, are strongly associated with nondiabetic kidney disease in individuals with recent African ancestry. Consistent with its role in trypanosome killing, the pro-death APOL1 protein is toxic to most cell...

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Bibliographic Details
Published in:J Lipid Res
Main Authors: Cheng, Dongmei, Weckerle, Allison, Yu, Yi, Ma, Lijun, Zhu, Xuewei, Murea, Mariana, Freedman, Barry I., Parks, John S., Shelness, Gregory S.
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2015
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513999/
https://ncbi.nlm.nih.gov/pubmed/26089538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M059733
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