Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-γ

Maladaptive repair after AKI may lead to progressive fibrosis and decline in kidney function. Sphingosine 1-phosphate has an important role in kidney injury and pleiotropic effects in fibrosis. We investigated the involvement of sphingosine kinase 1 and 2 (SphK1 and SphK2), which phosphorylate sphin...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Bajwa, Amandeep, Huang, Liping, Kurmaeva, Elvira, Ye, Hong, Dondeti, Krishna R., Chroscicki, Piotr, Foley, Leah S., Balogun, Z. Ayoade, Alexander, Kyle J., Park, Hojung, Lynch, Kevin R., Rosin, Diane L., Okusa, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2017
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373443/
https://ncbi.nlm.nih.gov/pubmed/27799486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016030306
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