Activation of Sphingosine-1-Phosphate 1 Receptor in the Proximal Tubule Protects Against Ischemia-Reperfusion Injury

Agonists of the sphingosine-1-phosphate receptor (S1PR) attenuate kidney ischemia-reperfusion injury (IRI). Previous studies suggested that S1P(1)R-induced lymphopenia mediates this protective effect, but lymphocyte-independent mechanisms could also contribute. Here, we investigated the effects of S...

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Autori principali: Bajwa, Amandeep, Jo, Sang-Kyung, Ye, Hong, Huang, Liping, Dondeti, Krishna R., Rosin, Diane L., Haase, Volker H., Macdonald, Timothy L., Lynch, Kevin R., Okusa, Mark D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2010
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900956/
https://ncbi.nlm.nih.gov/pubmed/20338995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009060662
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