ENL links histone acetylation to oncogenic gene expression in AML

Cancer cells are characterized by aberrant epigenetic landscapes and often exploit chromatin machinery to activate oncogenic gene expression programs(1). Recognition of modified histones by “reader” proteins constitutes a key mechanism underlying these processes; therefore, targeting such pathways h...

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Vydáno v:Nature
Hlavní autoři: Wan, Liling, Wen, Hong, Li, Yuanyuan, Lyu, Jie, Xi, Yuanxin, Hoshii, Takayuki, Joseph, Julia, Wang, Xiaolu, Loh, Yong-Hwee E., Erb, Michael A., Souza, Amanda L., Bradner, James E., Shen, Li, Li, Wei, Li, Haitao, Allis, C. David, Armstrong, Scott A., Shi, Xiaobing
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5372383/
https://ncbi.nlm.nih.gov/pubmed/28241141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21687
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