ENL links histone acetylation to oncogenic gene expression in AML

Cancer cells are characterized by aberrant epigenetic landscapes and often exploit chromatin machinery to activate oncogenic gene expression programs(1). Recognition of modified histones by “reader” proteins constitutes a key mechanism underlying these processes; therefore, targeting such pathways h...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Wan, Liling, Wen, Hong, Li, Yuanyuan, Lyu, Jie, Xi, Yuanxin, Hoshii, Takayuki, Joseph, Julia, Wang, Xiaolu, Loh, Yong-Hwee E., Erb, Michael A., Souza, Amanda L., Bradner, James E., Shen, Li, Li, Wei, Li, Haitao, Allis, C. David, Armstrong, Scott A., Shi, Xiaobing
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5372383/
https://ncbi.nlm.nih.gov/pubmed/28241141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21687
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