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5′-end NAD(+) cap in human cells promotes RNA decay through DXO-mediated deNADding
Eukaryotic mRNAs generally possess a 5′-end m(7)G cap that promotes their translation and stability. However, mammalian mRNAs can also carry a 5′-end nicotinamide adenine dinucleotide (NAD(+)) cap that, in contrast to the m(7)G cap, does not support translation but instead promotes mRNA decay. The m...
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| Publicado en: | Cell |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5371429/ https://ncbi.nlm.nih.gov/pubmed/28283058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.02.019 |
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