5′-end NAD(+) cap in human cells promotes RNA decay through DXO-mediated deNADding

Eukaryotic mRNAs generally possess a 5′-end m(7)G cap that promotes their translation and stability. However, mammalian mRNAs can also carry a 5′-end nicotinamide adenine dinucleotide (NAD(+)) cap that, in contrast to the m(7)G cap, does not support translation but instead promotes mRNA decay. The m...

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Vydáno v:Cell
Hlavní autoři: Jiao, Xinfu, Doamekpor, Selom K., Bird, Jeremy G., Nickels, Bryce E., Tong, Liang, Hart, Ronald P., Kiledjian, Megerditch
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5371429/
https://ncbi.nlm.nih.gov/pubmed/28283058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.02.019
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