Structural and mechanistic basis of the mammalian Nudt12 RNA deNADding

We recently demonstrated mammalian cells harbor NAD-capped mRNAs that are hydrolyzed by the DXO deNADding enzyme. Here we report the Nudix protein Nudt12 is a second mammalian deNADding enzyme structurally and mechanistically distinct from DXO and targeting different RNAs. Crystal structure of mouse...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Chem Biol
Hlavní autoři: Grudzien-Nogalska, Ewa, Wu, Yixuan, Jiao, Xinfu, Cui, Huijuan, Mateyak, Maria K., Hart, Ronald P., Tong, Liang, Kiledjian, Megerditch
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527130/
https://ncbi.nlm.nih.gov/pubmed/31101919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0293-7
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky