Structural and mechanistic basis of the mammalian Nudt12 RNA deNADding

We recently demonstrated mammalian cells harbor NAD-capped mRNAs that are hydrolyzed by the DXO deNADding enzyme. Here we report the Nudix protein Nudt12 is a second mammalian deNADding enzyme structurally and mechanistically distinct from DXO and targeting different RNAs. Crystal structure of mouse...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Chem Biol
Egile Nagusiak: Grudzien-Nogalska, Ewa, Wu, Yixuan, Jiao, Xinfu, Cui, Huijuan, Mateyak, Maria K., Hart, Ronald P., Tong, Liang, Kiledjian, Megerditch
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527130/
https://ncbi.nlm.nih.gov/pubmed/31101919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0293-7
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