Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs

We recently reported the presence of nicotinamide adenine dinucleotide (NAD)-capped RNAs in mammalian cells and a role for DXO and the Nudix hydrolase Nudt12 in decapping NAD-capped RNAs (deNADding) in cells. Analysis of 5′caps has revealed that in addition to NAD, mammalian RNAs also contain other...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Sharma, Sunny, Grudzien-Nogalska, Ewa, Hamilton, Keith, Jiao, Xinfu, Yang, Jun, Tong, Liang, Kiledjian, Megerditch
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337524/
https://ncbi.nlm.nih.gov/pubmed/32432673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa402
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