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Polymorphism at 129 dictates metastable conformations of the human prion protein N-terminal β-sheet
We study the thermodynamic stability of the native state of the human prion protein using a new free-energy method, replica-exchange on-the-fly parameterization. This method is designed to overcome hidden-variable sampling limitations to yield nearly error-free free-energy profiles along a conformat...
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| Publicado no: | Chem Sci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5369536/ https://ncbi.nlm.nih.gov/pubmed/28451263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc03275c |
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