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Burial of the Polymorphic Residue 129 in Amyloid Fibrils of Prion Stop Mutants
Misfolding of the natively α-helical prion protein into a β-sheet rich isoform is related to various human diseases such as Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker syndrome. In humans, the disease phenotype is modified by a methionine/valine polymorphism at codon 129 of the prio...
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Autors principals: | , , , , , , , , , |
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Format: | Artigo |
Idioma: | Inglês |
Publicat: |
American Society for Biochemistry and Molecular Biology
2013
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Matèries: | |
Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3561524/ https://ncbi.nlm.nih.gov/pubmed/23209282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.423715 |
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