Burial of the Polymorphic Residue 129 in Amyloid Fibrils of Prion Stop Mutants

Misfolding of the natively α-helical prion protein into a β-sheet rich isoform is related to various human diseases such as Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker syndrome. In humans, the disease phenotype is modified by a methionine/valine polymorphism at codon 129 of the prio...

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Главные авторы: Skora, Lukasz, Fonseca-Ornelas, Luis, Hofele, Romina V., Riedel, Dietmar, Giller, Karin, Watzlawik, Jens, Schulz-Schaeffer, Walter J., Urlaub, Henning, Becker, Stefan, Zweckstetter, Markus
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2013
Предметы:
Protein Structure and Folding
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561524/
https://ncbi.nlm.nih.gov/pubmed/23209282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.423715
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