Conformational Stability of Mammalian Prion Protein Amyloid Fibrils Is Dictated by a Packing Polymorphism within the Core Region

Mammalian prion strains are believed to arise from the propagation of distinct conformations of the misfolded prion protein PrP(Sc). One key operational parameter used to define differences between strains has been conformational stability of PrP(Sc) as defined by resistance to thermal and/or chemic...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Cobb, Nathan J., Apostol, Marcin I., Chen, Shugui, Smirnovas, Vytautas, Surewicz, Witold K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2014
Gaiak:
Protein Structure and Folding
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908398/
https://ncbi.nlm.nih.gov/pubmed/24338015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520718
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