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NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors
There are no clinically useful inhibitors of metallo-β-lactamases (MBLs), which are a growing problem because they hydrolyse almost all β-lactam antibacterials. Inhibition by most reported MBL inhibitors involves zinc ion chelation. A structure-based virtual screening approach combined with NMR filt...
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| Publicado en: | Chem Sci |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Royal Society of Chemistry
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5369532/ https://ncbi.nlm.nih.gov/pubmed/28451231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc04524c |
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