Structural basis of PDZ-mediated chemokine receptor CXCR2 scaffolding by guanine nucleotide exchange factor PDZ-RhoGEF

The CXC chemokine receptor 2 (CXCR2) is a G protein coupled receptor mediating interleukin-8 chemotactic signaling and plays an important role in neutrophil mobility and tumor migration. However, efficient CXCR2 signaling requires PDZ domain-mediated scaffolding of signaling complexes at the plasma...

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Veröffentlicht in:Biochem Biophys Res Commun
Hauptverfasser: Spellmon, Nicholas, Holcomb, Joshua, Niu, Andrea, Choudhary, Vishakha, Sun, Xiaonan, Zhang, Yingxue, Wan, Junmei, Doughan, Maysaa, Hayden, Stephanie, Hachem, Fatme, Brunzelle, Joseph, Li, Chunying, Yang, Zhe
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367461/
https://ncbi.nlm.nih.gov/pubmed/28179147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2017.02.010
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