Pharmacokinetic Modeling and Limited Sampling Strategies Based on Healthy Volunteers for Monitoring of Ertapenem in Patients with Multidrug-Resistant Tuberculosis

Ertapenem is a broad-spectrum carbapenem antibiotic whose activity against Mycobacterium tuberculosis is being explored. Carbapenems have antibacterial activity when the plasma concentration exceeds the MIC at least 40% of the time (40% T(MIC)). To assess the 40% T(MIC) in multidrug-resistant tuberc...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: van Rijn, S. P., Zuur, M. A., van Altena, R., Akkerman, O. W., Proost, J. H., de Lange, W. C. M., Kerstjens, H. A. M., Touw, D. J., van der Werf, T. S., Kosterink, J. G. W., Alffenaar, J. W. C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365678/
https://ncbi.nlm.nih.gov/pubmed/28137814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01783-16
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