Pharmacokinetic Modeling and Limited Sampling Strategies Based on Healthy Volunteers for Monitoring of Ertapenem in Patients with Multidrug-Resistant Tuberculosis

Ertapenem is a broad-spectrum carbapenem antibiotic whose activity against Mycobacterium tuberculosis is being explored. Carbapenems have antibacterial activity when the plasma concentration exceeds the MIC at least 40% of the time (40% T(MIC)). To assess the 40% T(MIC) in multidrug-resistant tuberc...

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Enregistré dans:
Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: van Rijn, S. P., Zuur, M. A., van Altena, R., Akkerman, O. W., Proost, J. H., de Lange, W. C. M., Kerstjens, H. A. M., Touw, D. J., van der Werf, T. S., Kosterink, J. G. W., Alffenaar, J. W. C.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2017
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365678/
https://ncbi.nlm.nih.gov/pubmed/28137814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01783-16
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