Pharmacokinetic Modeling and Limited Sampling Strategies Based on Healthy Volunteers for Monitoring of Ertapenem in Patients with Multidrug-Resistant Tuberculosis

Ertapenem is a broad-spectrum carbapenem antibiotic whose activity against Mycobacterium tuberculosis is being explored. Carbapenems have antibacterial activity when the plasma concentration exceeds the MIC at least 40% of the time (40% T(MIC)). To assess the 40% T(MIC) in multidrug-resistant tuberc...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: van Rijn, S. P., Zuur, M. A., van Altena, R., Akkerman, O. W., Proost, J. H., de Lange, W. C. M., Kerstjens, H. A. M., Touw, D. J., van der Werf, T. S., Kosterink, J. G. W., Alffenaar, J. W. C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2017
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365678/
https://ncbi.nlm.nih.gov/pubmed/28137814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01783-16
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