Pharmacokinetic Modeling and Limited Sampling Strategies Based on Healthy Volunteers for Monitoring of Ertapenem in Patients with Multidrug-Resistant Tuberculosis

Ertapenem is a broad-spectrum carbapenem antibiotic whose activity against Mycobacterium tuberculosis is being explored. Carbapenems have antibacterial activity when the plasma concentration exceeds the MIC at least 40% of the time (40% T(MIC)). To assess the 40% T(MIC) in multidrug-resistant tuberc...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: van Rijn, S. P., Zuur, M. A., van Altena, R., Akkerman, O. W., Proost, J. H., de Lange, W. C. M., Kerstjens, H. A. M., Touw, D. J., van der Werf, T. S., Kosterink, J. G. W., Alffenaar, J. W. C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365678/
https://ncbi.nlm.nih.gov/pubmed/28137814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01783-16
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