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Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis
BACKGROUND: Lysine-specific histone demethylase 1 (LSD1) modulates chromatin status through demethylation of H3K4 and H3K9. It has been demonstrated that LSD1 is hyperphosphorylated and dissociates from chromatin during mitosis. However, the molecular mechanism of LSD1 detachment is unknown. RESULTS...
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| Izdano u: | Cell Biosci |
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| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5364692/ https://ncbi.nlm.nih.gov/pubmed/28344766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-017-0142-x |
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