Polo-like kinase 1 (PLK1)-dependent phosphorylation of methylenetetrahydrofolate reductase (MTHFR) regulates replication via histone methylation

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating the folate cycle and its genetic variations have been associated with various human diseases. Previously we identified that MTHFR is phosphorylated by cyclin-dependent kinase 1 (CDK1) at T34 and MTHFR underlies heterochromatin ma...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Li, Xueyan, Nai, Shanshan, Ding, Yuehe, Geng, Qizhi, Zhu, Bingtao, Yu, Kai, Zhu, Wei-Guo, Dong, Meng-Qiu, Su, Xiao-Dong, Xu, Xingzhi, Li, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638376/
https://ncbi.nlm.nih.gov/pubmed/28820331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1363942
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