Chk2-dependent phosphorylation of myosin phosphatase targeting subunit 1 (MYPT1) regulates centrosome maturation

Checkpoint kinase 2 (Chk2) is a pivotal effector kinase in the DNA damage response, with an emerging role in mitotic chromosome segregation. In this study, we show that Chk2 interacts with myosin phosphatase targeting subunit 1 (MYPT1), the targeting subunit of protein phosphatase 1cβ (PP1cβ). Previ...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Nai, Shanshan, Shi, Yingxin, Ru, Huanwei, Ding, Yuehe, Geng, Qizhi, Li, Zhe, Dong, Meng-Qiu, Xu, Xingzhi, Li, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773232/
https://ncbi.nlm.nih.gov/pubmed/31416392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2019.1654795
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