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Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis

BACKGROUND: Lysine-specific histone demethylase 1 (LSD1) modulates chromatin status through demethylation of H3K4 and H3K9. It has been demonstrated that LSD1 is hyperphosphorylated and dissociates from chromatin during mitosis. However, the molecular mechanism of LSD1 detachment is unknown. RESULTS...

詳細記述

保存先:
書誌詳細
出版年:Cell Biosci
主要な著者: Peng, Bin, Shi, Ruifeng, Jiang, Weiwei, Ding, Yue-He, Dong, Meng-Qiu, Zhu, Wei-Guo, Xu, Xingzhi
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364692/
https://ncbi.nlm.nih.gov/pubmed/28344766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-017-0142-x
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