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Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis
BACKGROUND: Lysine-specific histone demethylase 1 (LSD1) modulates chromatin status through demethylation of H3K4 and H3K9. It has been demonstrated that LSD1 is hyperphosphorylated and dissociates from chromatin during mitosis. However, the molecular mechanism of LSD1 detachment is unknown. RESULTS...
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| 出版年: | Cell Biosci |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5364692/ https://ncbi.nlm.nih.gov/pubmed/28344766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-017-0142-x |
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