Interactions between Zinc and Allosteric Modulators of the Glycine Receptor

The glycine receptor is a pentameric ligand-gated ion channel that is involved in fast inhibitory neurotransmission in the central nervous system. Zinc is an allosteric modulator of glycine receptor function, enhancing the effects of glycine at nanomolar to low-micromolar concentrations and inhibiti...

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Bibliographic Details
Published in:J Pharmacol Exp Ther
Main Authors: Cornelison, Garrett L., Daszkowski, Anna W., Pflanz, Natasha C., Mihic, S. John
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2017
Subjects:
Neuropharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363777/
https://ncbi.nlm.nih.gov/pubmed/28087784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.239152
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