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An intersubunit electrostatic interaction in the GABA(A) receptor facilitates its responses to benzodiazepines
Benzodiazepines are positive allosteric modulators of the GABA(A) receptor (GABA(A)R), acting at the α–γ subunit interface to enhance GABA(A)R function. GABA or benzodiazepine binding induces distinct conformational changes in the GABA(A)R. The molecular rearrangements in the GABA(A)R following benz...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Biol Chem |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Biochemistry and Molecular Biology
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5971448/ https://ncbi.nlm.nih.gov/pubmed/29622679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002128 |
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