An intersubunit electrostatic interaction in the GABA(A) receptor facilitates its responses to benzodiazepines

Benzodiazepines are positive allosteric modulators of the GABA(A) receptor (GABA(A)R), acting at the α–γ subunit interface to enhance GABA(A)R function. GABA or benzodiazepine binding induces distinct conformational changes in the GABA(A)R. The molecular rearrangements in the GABA(A)R following benz...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Pflanz, Natasha C., Daszkowski, Anna W., Cornelison, Garrett L., Trudell, James R., Mihic, S. John
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2018
Konular:
Neurobiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971448/
https://ncbi.nlm.nih.gov/pubmed/29622679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002128
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