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Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation
Proper regulation of neurotransmission requires that ligand-activated ion channels remain closed until agonist binds. How channels then open remains poorly understood. Glycine receptor (GlyR) gating is initiated by agonist binding at interfaces between adjacent subunits in the extracellular domain....
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2867890/ https://ncbi.nlm.nih.gov/pubmed/20385800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001845107 |
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