Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation

Proper regulation of neurotransmission requires that ligand-activated ion channels remain closed until agonist binds. How channels then open remains poorly understood. Glycine receptor (GlyR) gating is initiated by agonist binding at interfaces between adjacent subunits in the extracellular domain....

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Detaylı Bibliyografya
Asıl Yazarlar: Todorovic, Jelena, Welsh, Brian T., Bertaccini, Edward J., Trudell, James R., Mihic, S. John
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2010
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867890/
https://ncbi.nlm.nih.gov/pubmed/20385800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001845107
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