Positive Allosteric Modulators Differentially Affect Full versus Partial Agonist Activation of the Glycine Receptor

Taurine acts as a partial agonist at the glycine receptor (GlyR) in some brain regions such as the hippocampus, striatum, and nucleus accumbens. Ethanol, volatile anesthetics, and inhaled drugs of abuse are all known positive allosteric modulators of GlyRs, but their effects on taurine-activated Gly...

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Detaylı Bibliyografya
Asıl Yazarlar: Kirson, Dean, Todorovic, Jelena, Mihic, S. John
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2012
Konular:
Neuropharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383033/
https://ncbi.nlm.nih.gov/pubmed/22473615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.191486
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