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Positive Allosteric Modulators Differentially Affect Full versus Partial Agonist Activation of the Glycine Receptor
Taurine acts as a partial agonist at the glycine receptor (GlyR) in some brain regions such as the hippocampus, striatum, and nucleus accumbens. Ethanol, volatile anesthetics, and inhaled drugs of abuse are all known positive allosteric modulators of GlyRs, but their effects on taurine-activated Gly...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Pharmacology and Experimental Therapeutics
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3383033/ https://ncbi.nlm.nih.gov/pubmed/22473615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.191486 |
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