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Disruption of a putative intersubunit electrostatic bond enhances agonist efficacy at the human α1 glycine receptor
Partial agonists have lower efficacies than compounds considered ‘full agonists’, eliciting submaximal responses even at saturating concentrations. Taurine is a partial agonist at the glycine receptor (GlyR), a member of the cys-loop ligand-gated ion channel superfamily. The molecular mechanisms res...
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| Publicado no: | Brain Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5303145/ https://ncbi.nlm.nih.gov/pubmed/27923639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2016.11.024 |
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