Optimization of a Neural Stem-Cell-Mediated Carboxylesterase/Irinotecan Gene Therapy for Metastatic Neuroblastoma

Despite improved survival for children with newly diagnosed neuroblastoma (NB), recurrent disease is a significant problem, with treatment options limited by anti-tumor efficacy, patient drug tolerance, and cumulative toxicity. We previously demonstrated that neural stem cells (NSCs) expressing a mo...

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Bibliografiske detaljer
Udgivet i:Mol Ther Oncolytics
Main Authors: Gutova, Margarita, Goldstein, Leanne, Metz, Marianne, Hovsepyan, Anahit, Tsurkan, Lyudmila G., Tirughana, Revathiswari, Tsaturyan, Lusine, Annala, Alexander J., Synold, Timothy W., Wan, Zesheng, Seeger, Robert, Anderson, Clarke, Moats, Rex A., Potter, Philip M., Aboody, Karen S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2016
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363723/
https://ncbi.nlm.nih.gov/pubmed/28345025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2016.11.004
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