STEM-32. PRE-CLINICAL SAFETY AND EFFICACY STUDIES OF NEURAL STEM CELL MEDIATED CARBOXYLESTERASE/IRINOTECAN ENZYME/PRODRUG GENE THERAPY FOR RECURRENT GLIOMA LEADING TO FIRST-IN-HUMAN PHASE I CLINICAL TRIAL

Human neural stem cells (NSCs) are inherently tumor-tropic, localizing to invasive brain tumor foci following intracerebral administration in preclinical models of primary and secondary brain tumors, thus overcoming obstacles limiting current therapeutic modalities. These NSCs can be engineered to e...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Ghoda, Lucy, Metz, Marianne, Tirughana, Revathiswari, Aramburo, Soraya, Gilchrist, Megan, Gutova, Margarita, Synold, Timothy, Barish, Michael, Brown, Christine, D’Apuzzo, Massimo, Moats, Rex, Potter, Phil, Blanchard, Suzette, Portnow, Jana, Aboody, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Abstracts
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693135/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.947
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