STEM-32. PRE-CLINICAL SAFETY AND EFFICACY STUDIES OF NEURAL STEM CELL MEDIATED CARBOXYLESTERASE/IRINOTECAN ENZYME/PRODRUG GENE THERAPY FOR RECURRENT GLIOMA LEADING TO FIRST-IN-HUMAN PHASE I CLINICAL TRIAL

Human neural stem cells (NSCs) are inherently tumor-tropic, localizing to invasive brain tumor foci following intracerebral administration in preclinical models of primary and secondary brain tumors, thus overcoming obstacles limiting current therapeutic modalities. These NSCs can be engineered to e...

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Pubblicato in:Neuro Oncol
Autori principali: Ghoda, Lucy, Metz, Marianne, Tirughana, Revathiswari, Aramburo, Soraya, Gilchrist, Megan, Gutova, Margarita, Synold, Timothy, Barish, Michael, Brown, Christine, D’Apuzzo, Massimo, Moats, Rex, Potter, Phil, Blanchard, Suzette, Portnow, Jana, Aboody, Karen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Abstracts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693135/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.947
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