Neural Stem Cell-Mediated Delivery of Irinotecan-Activating Carboxylesterases to Glioma: Implications for Clinical Use

CPT-11 (irinotecan) has been investigated as a treatment for malignant brain tumors. However, limitations of CPT-11 therapy include low levels of the drug entering brain tumor sites and systemic toxicities associated with higher doses. Neural stem cells (NSCs) offer a novel way to overcome these obs...

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Detalhes bibliográficos
Main Authors: Metz, Marianne Z., Gutova, Margarita, Lacey, Simon F., Abramyants, Yelena, Vo, Tien, Gilchrist, Megan, Tirughana, Revathiswari, Ghoda, Lucy Y., Barish, Michael E., Brown, Christine E., Najbauer, Joseph, Potter, Philip M., Portnow, Jana, Synold, Timothy W., Aboody, Karen S.
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2013
Assuntos:
Enabling Technologies for Cell-Based Clinical Translation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841093/
https://ncbi.nlm.nih.gov/pubmed/24167321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2012-0177
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