Neural Stem Cell-Mediated Delivery of Irinotecan-Activating Carboxylesterases to Glioma: Implications for Clinical Use

CPT-11 (irinotecan) has been investigated as a treatment for malignant brain tumors. However, limitations of CPT-11 therapy include low levels of the drug entering brain tumor sites and systemic toxicities associated with higher doses. Neural stem cells (NSCs) offer a novel way to overcome these obs...

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Bibliografische gegevens
Hoofdauteurs: Metz, Marianne Z., Gutova, Margarita, Lacey, Simon F., Abramyants, Yelena, Vo, Tien, Gilchrist, Megan, Tirughana, Revathiswari, Ghoda, Lucy Y., Barish, Michael E., Brown, Christine E., Najbauer, Joseph, Potter, Philip M., Portnow, Jana, Synold, Timothy W., Aboody, Karen S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: AlphaMed Press 2013
Onderwerpen:
Enabling Technologies for Cell-Based Clinical Translation
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841093/
https://ncbi.nlm.nih.gov/pubmed/24167321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2012-0177
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