Neural Stem Cell-Mediated Delivery of Irinotecan-Activating Carboxylesterases to Glioma: Implications for Clinical Use

CPT-11 (irinotecan) has been investigated as a treatment for malignant brain tumors. However, limitations of CPT-11 therapy include low levels of the drug entering brain tumor sites and systemic toxicities associated with higher doses. Neural stem cells (NSCs) offer a novel way to overcome these obs...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Metz, Marianne Z., Gutova, Margarita, Lacey, Simon F., Abramyants, Yelena, Vo, Tien, Gilchrist, Megan, Tirughana, Revathiswari, Ghoda, Lucy Y., Barish, Michael E., Brown, Christine E., Najbauer, Joseph, Potter, Philip M., Portnow, Jana, Synold, Timothy W., Aboody, Karen S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: AlphaMed Press 2013
Pynciau:
Enabling Technologies for Cell-Based Clinical Translation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841093/
https://ncbi.nlm.nih.gov/pubmed/24167321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2012-0177
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