Neural Stem Cell-Mediated Delivery of Irinotecan-Activating Carboxylesterases to Glioma: Implications for Clinical Use

CPT-11 (irinotecan) has been investigated as a treatment for malignant brain tumors. However, limitations of CPT-11 therapy include low levels of the drug entering brain tumor sites and systemic toxicities associated with higher doses. Neural stem cells (NSCs) offer a novel way to overcome these obs...

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Bibliografiset tiedot
Päätekijät: Metz, Marianne Z., Gutova, Margarita, Lacey, Simon F., Abramyants, Yelena, Vo, Tien, Gilchrist, Megan, Tirughana, Revathiswari, Ghoda, Lucy Y., Barish, Michael E., Brown, Christine E., Najbauer, Joseph, Potter, Philip M., Portnow, Jana, Synold, Timothy W., Aboody, Karen S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: AlphaMed Press 2013
Aiheet:
Enabling Technologies for Cell-Based Clinical Translation
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841093/
https://ncbi.nlm.nih.gov/pubmed/24167321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2012-0177
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