Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell–Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury

Reliable and versatile hepatic in vitro systems for the prediction of drug pharmacokinetics and toxicity are essential constituents of preclinical safety assessment pipelines for new medicines. Here, we compared three emerging cell systems—hepatocytes derived from induced pluripotent stem cells, Hep...

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Publicado en:Drug Metab Dispos
Autores principales: Bell, Catherine C., Lauschke, Volker M., Vorrink, Sabine U., Palmgren, Henrik, Duffin, Rodger, Andersson, Tommy B., Ingelman-Sundberg, Magnus
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2017
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363699/
https://ncbi.nlm.nih.gov/pubmed/28137721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.074369
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