Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell–Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury

Reliable and versatile hepatic in vitro systems for the prediction of drug pharmacokinetics and toxicity are essential constituents of preclinical safety assessment pipelines for new medicines. Here, we compared three emerging cell systems—hepatocytes derived from induced pluripotent stem cells, Hep...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Bell, Catherine C., Lauschke, Volker M., Vorrink, Sabine U., Palmgren, Henrik, Duffin, Rodger, Andersson, Tommy B., Ingelman-Sundberg, Magnus
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363699/
https://ncbi.nlm.nih.gov/pubmed/28137721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.074369
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