Determination of receptor occupancy in the presence of mass dose: [(11)C]GSK189254 PET imaging of histamine H(3) receptor occupancy by PF-03654746

Measurements of drug occupancies using positron emission tomography (PET) can be biased if the radioligand concentration exceeds “tracer” levels. Negative bias would also arise in successive PET scans if clearance of the radioligand is slow, resulting in a carryover effect. We developed a method to...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Gallezot, Jean-Dominique, Planeta, Beata, Nabulsi, Nabeel, Palumbo, Donna, Li, Xiaoxi, Liu, Jing, Rowinski, Carolyn, Chidsey, Kristin, Labaree, David, Ropchan, Jim, Lin, Shu-Fei, Sawant-Basak, Aarti, McCarthy, Timothy J, Schmidt, Anne W, Huang, Yiyun, Carson, Richard E
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363483/
https://ncbi.nlm.nih.gov/pubmed/27207170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16650697
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