Evaluation of the Agonist PET Radioligand [(11)C]GR103545 to Image Kappa Opioid Receptor in Humans: Kinetic Model Selection, Test-Retest Reproducibility and Receptor Occupancy by the Antagonist PF-04455242

INTRODUCTION: Kappa opioid receptors (KOR) are implicated in several brain disorders. In this report, a first-in-human Positron Emission Tomography (PET) study was conducted with the potent and selective KOR agonist tracer, [(11)C]GR103545, to determine an appropriate kinetic model for analysis of P...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Naganawa, Mika, Jacobsen, Leslie K., Zheng, Ming-Qiang, Lin, Shu-Fei, Banerjee, Anindita, Byon, Wonkyung, Weinzimmer, David, Tomasi, Giampaolo, Nabulsi, Nabeel, Grimwood, Sarah, Badura, Lori L., Carson, Richard E., McCarthy, Timothy J., Huang, Yiyun
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140089/
https://ncbi.nlm.nih.gov/pubmed/24844744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2014.05.033
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados