Evaluation of the Agonist PET Radioligand [(11)C]GR103545 to Image Kappa Opioid Receptor in Humans: Kinetic Model Selection, Test-Retest Reproducibility and Receptor Occupancy by the Antagonist PF-04455242

INTRODUCTION: Kappa opioid receptors (KOR) are implicated in several brain disorders. In this report, a first-in-human Positron Emission Tomography (PET) study was conducted with the potent and selective KOR agonist tracer, [(11)C]GR103545, to determine an appropriate kinetic model for analysis of P...

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Main Authors: Naganawa, Mika, Jacobsen, Leslie K., Zheng, Ming-Qiang, Lin, Shu-Fei, Banerjee, Anindita, Byon, Wonkyung, Weinzimmer, David, Tomasi, Giampaolo, Nabulsi, Nabeel, Grimwood, Sarah, Badura, Lori L., Carson, Richard E., McCarthy, Timothy J., Huang, Yiyun
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140089/
https://ncbi.nlm.nih.gov/pubmed/24844744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2014.05.033
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