Improved Intravitreal AAV-Mediated Inner Retinal Gene Transduction after Surgical Internal Limiting Membrane Peeling in Cynomolgus Monkeys

The retina is an ideal target for gene therapy because of its easy accessibility and limited immunological response. We previously reported that intravitreally injected adeno-associated virus (AAV) vector transduced the inner retina with high efficiency in a rodent model. In large animals, however,...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Ther
Main Authors: Takahashi, Kazuhisa, Igarashi, Tsutomu, Miyake, Koichi, Kobayashi, Maika, Yaguchi, Chiemi, Iijima, Osamu, Yamazaki, Yoshiyuki, Katakai, Yuko, Miyake, Noriko, Kameya, Shuhei, Shimada, Takashi, Takahashi, Hiroshi, Okada, Takashi
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2017
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363307/
https://ncbi.nlm.nih.gov/pubmed/28129123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.10.008
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki