Adeno-associated virus type 8 vector–mediated expression of siRNA targeting vascular endothelial growth factor efficiently inhibits neovascularization in a murine choroidal neovascularization model

PURPOSE: To assess the feasibility of a gene therapeutic approach to treating choroidal neovascularization (CNV), we generated an adeno-associated virus type 8 vector (AAV2/8) encoding an siRNA targeting vascular endothelial growth factor (VEGF), and determined the AAV2/8 vector’s ability to inhibit...

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Autori principali: Igarashi, Tsutomu, Miyake, Noriko, Fujimoto, Chiaki, Yaguchi, Chiemi, Iijima, Osamu, Shimada, Takashi, Takahashi, Hiroshi, Miyake, Koichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Molecular Vision 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984039/
https://ncbi.nlm.nih.gov/pubmed/24744609
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