Improved Intravitreal AAV-Mediated Inner Retinal Gene Transduction after Surgical Internal Limiting Membrane Peeling in Cynomolgus Monkeys

The retina is an ideal target for gene therapy because of its easy accessibility and limited immunological response. We previously reported that intravitreally injected adeno-associated virus (AAV) vector transduced the inner retina with high efficiency in a rodent model. In large animals, however,...

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Publicado en:Mol Ther
Main Authors: Takahashi, Kazuhisa, Igarashi, Tsutomu, Miyake, Koichi, Kobayashi, Maika, Yaguchi, Chiemi, Iijima, Osamu, Yamazaki, Yoshiyuki, Katakai, Yuko, Miyake, Noriko, Kameya, Shuhei, Shimada, Takashi, Takahashi, Hiroshi, Okada, Takashi
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2017
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363307/
https://ncbi.nlm.nih.gov/pubmed/28129123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.10.008
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