Improved Intravitreal AAV-Mediated Inner Retinal Gene Transduction after Surgical Internal Limiting Membrane Peeling in Cynomolgus Monkeys

The retina is an ideal target for gene therapy because of its easy accessibility and limited immunological response. We previously reported that intravitreally injected adeno-associated virus (AAV) vector transduced the inner retina with high efficiency in a rodent model. In large animals, however,...

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Detaylı Bibliyografya
Yayımlandı:Mol Ther
Asıl Yazarlar: Takahashi, Kazuhisa, Igarashi, Tsutomu, Miyake, Koichi, Kobayashi, Maika, Yaguchi, Chiemi, Iijima, Osamu, Yamazaki, Yoshiyuki, Katakai, Yuko, Miyake, Noriko, Kameya, Shuhei, Shimada, Takashi, Takahashi, Hiroshi, Okada, Takashi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Gene & Cell Therapy 2017
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363307/
https://ncbi.nlm.nih.gov/pubmed/28129123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.10.008
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