Adeno-associated virus type 8 vector–mediated expression of siRNA targeting vascular endothelial growth factor efficiently inhibits neovascularization in a murine choroidal neovascularization model

PURPOSE: To assess the feasibility of a gene therapeutic approach to treating choroidal neovascularization (CNV), we generated an adeno-associated virus type 8 vector (AAV2/8) encoding an siRNA targeting vascular endothelial growth factor (VEGF), and determined the AAV2/8 vector’s ability to inhibit...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Igarashi, Tsutomu, Miyake, Noriko, Fujimoto, Chiaki, Yaguchi, Chiemi, Iijima, Osamu, Shimada, Takashi, Takahashi, Hiroshi, Miyake, Koichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Molecular Vision 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984039/
https://ncbi.nlm.nih.gov/pubmed/24744609
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge