KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

The mechanistic target of rapamycin complex 1 kinase (mTORC1) is a central regulator of cell growth that responds to diverse environmental signals and is deregulated in many human diseases, including cancer and epilepsy(1–3). Amino acids are a key input, and act through the Rag GTPases to promote th...

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Udgivet i:Nature
Main Authors: Wolfson, Rachel L., Chantranupong, Lynne, Wyant, Gregory A., Gu, Xin, Orozco, Jose M., Shen, Kuang, Condon, Kendall J., Petri, Sabrina, Kedir, Jibril, Scaria, Sonia M., Abu-Remaileh, Monther, Frankel, Wayne N., Sabatini, David M.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360989/
https://ncbi.nlm.nih.gov/pubmed/28199306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21423
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