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Diffusion of nucleoside triphosphates and role of the entry site to the RNA polymerase II active center

Nucleoside triphosphates (NTPs) diffuse to the active center of RNA polymerase II through a funnel-shaped opening that narrows to a negatively charged pore. Computer simulation shows that the funnel and pore reduce the rate of diffusion by a factor of ≈2 × 10(–7). The resulting limitation on the rat...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Batada, Nizar N., Westover, Kenneth D., Bushnell, David A., Levitt, Michael, Kornberg, Roger D.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC536049/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15574497/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408168101
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