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Diffusion of nucleoside triphosphates and role of the entry site to the RNA polymerase II active center

Nucleoside triphosphates (NTPs) diffuse to the active center of RNA polymerase II through a funnel-shaped opening that narrows to a negatively charged pore. Computer simulation shows that the funnel and pore reduce the rate of diffusion by a factor of ≈2 × 10(–7). The resulting limitation on the rat...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Batada, Nizar N., Westover, Kenneth D., Bushnell, David A., Levitt, Michael, Kornberg, Roger D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2004
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC536049/
https://ncbi.nlm.nih.gov/pubmed/15574497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408168101
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