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Diffusion of nucleoside triphosphates and role of the entry site to the RNA polymerase II active center
Nucleoside triphosphates (NTPs) diffuse to the active center of RNA polymerase II through a funnel-shaped opening that narrows to a negatively charged pore. Computer simulation shows that the funnel and pore reduce the rate of diffusion by a factor of ≈2 × 10(–7). The resulting limitation on the rat...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC536049/ https://ncbi.nlm.nih.gov/pubmed/15574497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408168101 |
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