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Templated nucleoside triphosphate binding to a noncatalytic site on RNA polymerase regulates transcription

The regulation of RNA synthesis by RNA polymerase (RNAP) is essential for proper gene expression. Crystal structures of RNAP reveal two channels: the main channel that contains the downstream DNA and a secondary channel that leads directly to the catalytic site. Although nucleoside triphosphates (NT...

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Detalles Bibliográficos
Main Authors: Kennedy, Scott R., Erie, Dorothy A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2011
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076813/
https://ncbi.nlm.nih.gov/pubmed/21447716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011274108
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