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The Alzheimer’s disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway
BACKGROUND: Triggering receptor expressed on myeloid cells 2 (TREM2) and apolipoprotein E (APOE) are genetically linked to Alzheimer’s disease. Here, we investigated whether human ApoE mediates signal transduction through human and murine TREM2 and sought to identify a TREM2-binding domain in human...
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| Publicado no: | J Neuroinflammation |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5360024/ https://ncbi.nlm.nih.gov/pubmed/28320424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0835-4 |
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