The Alzheimer’s disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway

BACKGROUND: Triggering receptor expressed on myeloid cells 2 (TREM2) and apolipoprotein E (APOE) are genetically linked to Alzheimer’s disease. Here, we investigated whether human ApoE mediates signal transduction through human and murine TREM2 and sought to identify a TREM2-binding domain in human...

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Publicat a:J Neuroinflammation
Autors principals: Jendresen, Charlotte, Årskog, Vibeke, Daws, Michael R., Nilsson, Lars N. G.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360024/
https://ncbi.nlm.nih.gov/pubmed/28320424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0835-4
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